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GEN Biotechnology. Aug 2023.301-316. http://doi.org/10.1089/genbio.2023.0020
Sivasami P, Elkins C, Diaz-Saldana PP, Goss K, Peng A, Hamersky M 4th, Bae J, Xu M, Pollack BP, Horwitz EM, Scharer CD, Seldin L, Li C. Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation. Immunity. 2023 Aug 8;56(8):1844-1861.e6. doi: 10.1016/j.immuni.2023.06.021. Epub 2023 Jul 20. PMID: 37478855; PMCID: PMC10527179.
Sivasami P, Elkins C, Diaz-Saldana PP, Goss K, Peng A, Hamersky M 4th, Bae J, Xu M, Pollack BP, Horwitz EM, Scharer CD, Seldin L, Li C. Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation. Immunity. 2023 Aug 8;56(8):1844-1861.e6. doi: 10.1016/j.immuni.2023.06.021. Epub 2023 Jul 20. PMID: 37478855.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544941. doi: 10.1101/2023.06.14.544941. PMID: 37398244; PMCID: PMC10312689.
Zuo Z, Kania AK, Patterson DG, Hicks SL, Maurer J, Gupta M, Boss JM, Scharer CD. CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation. Heliyon. 2023 Jun 21;9(6):e17527. doi: 10.1016/j.heliyon.2023.e17527. PMID: 37416674; PMCID: PMC10320122.
Nellore A, Zumaquero E, Scharer CD, Fucile CF, Tipton CM, King RG, Mi T, Mousseau B, Bradley JE, Zhou F, Mutneja S, Goepfert PA, Boss JM, Randall TD, Sanz I, Rosenberg AF, Lund FE. A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans. Immunity. 2023 Apr 11;56(4):847-863.e8. doi: 10.1016/j.immuni.2023.03.001. Epub 2023 Mar 22. PMID: 36958335; PMCID: PMC10113805.
Rose JR, Akdogan-Ozdilek B, Rahmberg AR, Powell MD, Hicks SL, Scharer CD, Boss JM. Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential. Commun Biol. 2023 Apr 3;6(1):363. doi: 10.1038/s42003-023-04747-9. PMID: 37012418; PMCID: PMC10070634.
Ware MB, Phillips M, McQuinn C, Zaidi MY, Knochelmann HM, Greene E, Robinson B, Herting CJ, Mace TA, Chen Z, Zhang C, Farren MR, Ruggieri AN, Bowers JS, Shakya R, Farris AB, Young G, Carson WE 3rd, El-Rayes B, Paulos CM, Lesinski GB. Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell- and CXCR3-dependent manner. JCI Insight. 2023 Apr 24;8(8):e155006. doi: 10.1172/jci.insight.155006. PMID: 36881480; PMCID: PMC10243806.
Zhu L, Zhao Y, Liu T, Chen M, Qian WP, Jiang B, Barwick BG, Zhang L, Styblo TM, Li X, Yang L. Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy. ACS Nano. 2022 Nov 22;16(11):18708-18728. doi: 10.1021/acsnano.2c07440. Epub 2022 Oct 18. PMID: 36256454; PMCID: PMC9764083.
Lobby JL, Uddbäck I, Scharer CD, Mi T, Boss JM, Thomsen AR, Christensen JP, Kohlmeier JE. Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells. J Immunol. 2022 Nov 1;209(9):1778-1787. doi: 10.4049/jimmunol.2200082. Epub 2022 Sep 26. PMID: 36162870; PMCID: PMC9588742.
Rotolo L, Vanover D, Bruno NC, Peck HE, Zurla C, Murray J, Noel RK, O'Farrell L, Araínga M, Orr-Burks N, Joo JY, Chaves LCS, Jung Y, Beyersdorf J, Gumber S, Guerrero-Ferreira R, Cornejo S, Thoresen M, Olivier AK, Kuo KM, Gumbart JC, Woolums AR, Villinger F, Lafontaine ER, Hogan RJ, Finn MG, Santangelo PJ. Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung. Nat Mater. 2022 Nov 28. doi: 10.1038/s41563-022-01404-0. Epub ahead of print. PMID: 36443576.
Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS. SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nat Commun. 2022 Nov 7;13(1):6707. doi: 10.1038/s41467-022-34578-x. PMID: 36344525; PMCID: PMC9640623.
Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R. PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. PMID: 36171288; PMCID: PMC9793890.
Werner E, Gokhale A, Ackert M, Xu C, Wen Z, Roberts AM, Roberts BR, Vrailas-Mortimer A, Crocker A, Faundez V. The mitochondrial RNA granule modulates manganese-dependent cell toxicity. Mol Biol Cell. 2022 Oct 1;33(12):ar108. doi: 10.1091/mbc.E22-03-0096. Epub 2022 Aug 3. PMID: 35921164; PMCID: PMC9635304.
Zinzow-Kramer WM, Kolawole EM, Eggert J, Evavold BD, Scharer CD, Au-Yeung BB. Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4+ T Cells. Immunohorizons. 2022 Sep 13;6(9):671-683. doi: 10.4049/immunohorizons.2200051. PMID: 36100367.
Zhou C, Uluisik R, Rowley JW, David C, Jones CL, Scharer CD, Noetzli L, Fisher MH, Kirkpatrick GD, Bark K, Boss JM, Henry CJ, Pietras EM, Di Paola J, Porter CC. Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Exp Hematol. 2022 Aug-Sep;112-113:24-34. doi: 10.1016/j.exphem.2022.06.002. Epub 2022 Jul 6. PMID: 35803545; PMCID: PMC9885892.
Lee M, Geitgey DK, Hamilton JAG, Boss JM, Scharer CD, Spangle JM, Haynes KA, Henry CJ. Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Front Cell Dev Biol. 2022 Aug 19;10:909557. doi: 10.3389/fcell.2022.909557. PMID: 36060800; PMCID: PMC9438935.
Gupta VA, Matulis SM, Barwick BG, Bog RD, Shebelut CW, Shanmugam M, Neri P, Bahlis NJ, Dhodapkar MV, Heffner LT, Hofmeister CC, Joseph NS, Lonial S, Kaufman JL, Jaye DL, Nooka AK, Boise LH. Venetoclax ex vivo functional profiling predicts improved progression-free survival. Blood Cancer J. 2022 Aug 4;12(8):115. doi: 10.1038/s41408-022-00710-9. PMID: 35927247; PMCID: PMC9352682.
Hunter R, Imbach KJ, Zhou C, Dougan J, Hamilton JAG, Chen KZ, Do P, Townsel A, Gibson G, Dreaden EC, Waller EK, Haynes KA, Henry CJ, Porter CC. B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12. Sci Rep. 2022 Jul 13;12(1):11870. doi: 10.1038/s41598-022-16152-z. PMID: 35831470; PMCID: PMC9279427.
Moser-Katz T, Gavile CM, Barwick BG, Lee KP, Boise LH. PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival. Mol Cancer Res. 2022 Jul 6;20(7):1122-1136. doi: 10.1158/1541-7786.MCR-21-0681. PMID: 35380688; PMCID: PMC9262820.
Bekhbat M, Ulukaya GB, Bhasin MK, Felger JC, Miller AH. Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen. Neurobiol Stress. 2022 May 24;19:100462. doi: 10.1016/j.ynstr.2022.100462. PMID: 35655933; PMCID: PMC9152104.
Minten EV, Yu DS. Protocol for in vitro lysine deacetylation to test putative substrates of class III deacetylases. STAR Protoc. 2022 Apr 13;3(2):101313. doi: 10.1016/j.xpro.2022.101313. PMID: 35496786; PMCID: PMC9038758.
Boya M, Ozkaya-Ahmadov T, Swain BE, Chu CH, Asmare N, Civelekoglu O, Liu R, Lee D, Tobia S, Biliya S, McDonald LD, Nazha B, Kucuk O, Sanda MG, Benigno BB, Moreno CS, Bilen MA, McDonald JF, Sarioglu AF. High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells. Nat Commun. 2022 Jun 13;13(1):3385. doi: 10.1038/s41467-022-31009-9. PMID: 35697674; PMCID: PMC9192591.
Zhang B, Xia S, Liu M, Li X, Shuai S, Tao W, Li Y, Ni JJ, Zhou W, Liao L, Xu J, Dong JT. Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling. J Genet Genomics. 2022 Jun;49(6):579-582. doi: 10.1016/j.jgg.2021.11.013. Epub 2021 Dec 21. PMID: 34952235.
Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B, Walton E, Mishra PP, Schlosser P, Wilson R, Tsai PC, Palaniswamy S, Marioni RE, Fiorito G, Cugliari G, Karhunen V, Ghanbari M, Psaty BM, Loh M, Bis JC, Lehne B, Sotoodehnia N, Deary IJ, Chadeau-Hyam M, Brody JA, Cardona A, Selvin E, Smith AK, Miller AH, Torres MA, Marouli E, Gào X, van Meurs JBJ, Graf-Schindler J, Rathmann W, Koenig W, Peters A, Weninger W, Farlik M, Zhang T, Chen W, Xia Y, Teumer A, Nauck M, Grabe HJ, Doerr M, Lehtimäki T, Guan W, Milani L, Tanaka T, Fisher K, Waite LL, Kasela S, Vineis P, Verweij N, van der Harst P, Iacoviello L, Sacerdote C, Panico S, Krogh V, Tumino R, Tzala E, Matullo G, Hurme MA, Raitakari OT, Colicino E, Baccarelli AA, Kähönen M, Herzig KH, Li S; BIOS consortium; Conneely KN, Kooner JS, Köttgen A, Heijmans BT, Deloukas P, Relton C, Ong KK, Bell JT, Boerwinkle E, Elliott P, Brenner H, Beekman M, Levy D, Waldenberger M, Chambers JC, Dehghan A, Järvelin MR. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. 2022 May 3;13(1):2408. doi: 10.1038/s41467-022-29792-6. PMID: 35504910; PMCID: PMC9065016.
Liu M, Starenki D, Scharer CD, Silva-Sanchez A, Molina PA, Pollock JS, Cooper SJ, Arend RC, Rosenberg AF, Randall TD, Meza-Perez S. Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features. Cancer Immunol Res. 2022 May 3;10(5):641-655. doi: 10.1158/2326-6066.CIR-21-0880. PMID: 35263766; PMCID: PMC9064962.
Dale GA, Wilkins DJ, Rowley J, Scharer CD, Tipton CM, Hom J, Boss JM, Corces V, Sanz I, Jacob J. Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. J Immunol. 2022 May 1;208(9):2141-2153. doi: 10.4049/jimmunol.2100434. Epub 2022 Apr 13. PMID: 35418472; PMCID: PMC9047068.
Kania AK, Price MJ, George-Alexander LE, Patterson DG, Hicks SL, Scharer CD, Boss JM. H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. J Immunol. 2022 Apr 15;208(8):1873-1885. doi: 10.4049/jimmunol.2100948. Epub 2022 Mar 28. PMID: 35346967; PMCID: PMC9012698.
Joyner CJ, Ley AM, Nguyen DC, Ali M, Corrado A, Tipton C, Scharer CD, Mi T, Woodruff MC, Hom J, Boss JM, Duan M, Gibson G, Roberts D, Andrews J, Lonial S, Sanz I, Lee FE. Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting. Life Sci Alliance. 2021 Dec 24;5(3):e202101285. doi: 10.26508/lsa.202101285. PMID: 34952892; PMCID: PMC8739272.
Lee M, Hamilton JAG, Talekar GR, Ross AJ, Michael L, Rupji M, Dwivedi B, Raikar SS, Boss J, Scharer CD, Graham DK, DeRyckere D, Porter CC, Henry CJ. Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nat Commun. 2022 Mar 3;13(1):1157. doi: 10.1038/s41467-022-28839-y. PMID: 35241678; PMCID: PMC8894417.
Zhang H, Dammer EB, Duong DM, Danelia D, Seyfried NT, Yu DS. Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates. Sci Rep. 2022 Mar 9;12(1):3822. doi: 10.1038/s41598-022-06793-5. PMID: 35264593; PMCID: PMC8907344.
Gohar J, Do WL, Miller-Kleinhenz J, Conneely K, Krishnamurti U, D'Angelo O, Gogineni K, Torres M, Gabram-Mendola S, McCullough LE. Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast Cancer Res Treat. 2022 Feb;191(3):653-663. doi: 10.1007/s10549-021-06430-1. Epub 2022 Jan 3. PMID: 34978015.
Di Pietro A, Polmear J, Cooper L, Damelang T, Hussain T, Hailes L, O'Donnell K, Udupa V, Mi T, Preston S, Shtewe A, Hershberg U, Turner SJ, La Gruta NL, Chung AW, Tarlinton DM, Scharer CD, Good-Jacobson KL. Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection. Nat Immunol. 2022 Jan;23(1):86-98. doi: 10.1038/s41590-021-01077-y. Epub 2021 Nov 29. PMID: 34845392.
Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, Gupta VA, Chandrakasan S, Zoine JT, Fedanov A, Raikar SS, Koff JL, Flowers CR, Coma S, Pachter JA, Ravindranathan S, Spencer HT, Shanmugam M, Waller EK. PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity. Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597. Erratum in: Blood. 2022 Sep 22;140(12):1449-1451. PMID: 35084470; PMCID: PMC8796652.
Kania AK, Guo M, Scharer CD, Boss JM. Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. Immunohorizons. 2021 Dec 8;5(12):918-930. doi: 10.4049/immunohorizons.2000087. PMID: 34880105; PMCID: PMC10197425.
Patterson DG, Kania AK, Price MJ, Rose JR, Scharer CD, Boss JM. An IRF4-MYC-mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo. J Immunol. 2021 Oct 1;207(7):1798-1811. doi: 10.4049/jimmunol.2100440. Epub 2021 Sep 1. PMID: 34470852; PMCID: PMC8455452.
Corrado A, Ramonell RP, Woodruff MC, Tipton C, Wise S, Levy J, DelGaudio J, Kuruvilla ME, Magliocca KR, Tomar D, Garimalla S, Scharer CD, Boss JM, Wu H, Gumber S, Fucile C, Gibson G, Rosenberg A, Sanz I, Lee FE. Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa. Mucosal Immunol. 2021 Sep;14(5):1144-1159. doi: 10.1038/s41385-021-00410-w. Epub 2021 May 28. PMID: 34050324; PMCID: PMC8160425.
Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, Xu T, Raj N, Zhang F, Dou J, Xu C, Wu H, Bassell GJ, Warren ST, Allen EG, Jin P, Wen Z. A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. Nat Neurosci. 2021 Aug 19. doi: 10.1038/s41593-021-00913-6. Epub ahead of print. PMID: 34413513.
Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J. NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. JCI Insight. 2021 Aug 3:151005. doi: 10.1172/jci.insight.151005. Epub ahead of print. PMID: 34343134.
Price MJ, Scharer CD, Kania AK, Randall TD, Boss JM. Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation. J Immunol. 2021 Apr 1;206(7):1493-1504. doi: 10.4049/jimmunol.2000551. Epub 2021 Feb 24. PMID: 33627377; PMCID: PMC7988296.
Andueza A, Kumar S, Kim J, Kang DW, Mumme HL, Perez JI, Villa-Roel N, Jo H. Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study. Cell Rep. 2020 Dec 15;33(11):108491. doi: 10.1016/j.celrep.2020.108491. PMID: 33326796; PMCID: PMC7801938.
Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. J Biol Chem. 2021 Jan-Jun;296:100024. doi: 10.1074/jbc.RA120.016009. Epub 2020 Nov 22. PMID: 33410399; PMCID: PMC7949046.
Vigneswaran K, Boyd NH, Oh SY, Lallani S, Boucher A, Neill SG, Olson JJ, Read RD. YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma. Clin Cancer Res. 2021 Mar 1;27(5):1553-1569. doi: 10.1158/1078-0432.CCR-20-0018. Epub 2020 Nov 10. PMID: 33172899.
Scharer CD, Fortner KA, Dragon JA, Tighe S, Boss JM, Budd RC. Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice. Immunohorizons. 2020 Oct 23;4(10):679-687. doi: 10.4049/immunohorizons.2000078. PMID: 33097564; PMCID: PMC8141279.
Babiker A, Bradley HL, Stittleburg VD, Ingersoll JM, Key A, Kraft CS, Waggoner JJ, Piantadosi A. Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19. J Clin Microbiol. 2020 Oct 16:JCM.02142-20. doi: 10.1128/JCM.02142-20. Epub ahead of print. PMID: 33067271.
Zhang Y, Ware MB, Zaidi MY, Ruggieri AN, Olson BM, Komar H, Farren MR, Nagaraju GP, Zhang C, Chen Z, Sarmiento JM, Ahmed R, Maithel SK, El-Rayes BF, Lesinski GB. Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer. Mol Cancer Ther. 2021 Jan;20(1):150-160. doi: 10.1158/1535-7163.MCT-19-0911. Epub 2020 Oct 9. PMID: 33037138; PMCID: PMC7790996..
Bai J, Bruner DW, Fedirko V, Beitler JJ, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Higgins KA, Shin DM, Saba NF, Miller AH, Xiao C. Gut Microbiome Associated with the Psychoneurological Symptom Cluster in Patients with Head and Neck Cancers. Cancers (Basel). 2020 Sep 6;12(9):2531. doi: 10.3390/cancers12092531. PMID: 32899975; PMCID: PMC7563252..
Baurley JW, Kjærsgaard A, Zwick ME, Cronin-Fenton DP, Collin LJ, Damkier P, Hamilton-Dutoit S, Lash TL, Ahern TP. Bayesian Pathway Analysis for Complex Interactions. Am J Epidemiol. 2020 Dec 1;189(12):1610-1622. doi: 10.1093/aje/kwaa130. PMID: 32639515; PMCID: PMC7822643.
Scharer CD, Patterson DG, Mi T, Price MJ, Hicks SL, Boss JM. Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nat Commun. 2020 Aug 10;11(1):3989. doi: 10.1038/s41467-020-17798-x. PMID: 32778653; PMCID: PMC7417592.
Inglis GAS, Zhou Y, Patterson DG, Scharer CD, Han Y, Boss JM, Wen Z, Escayg A. Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons. Hum Mol Genet. 2020 Aug 29;29(15):2579-2595. doi: 10.1093/hmg/ddaa150. PMID: 32794569; PMCID: PMC7471504.
Obeng RC, Arnold RS, Ogan K, Master VA, Pattaras JG, Petros JA, Osunkoya AO. Molecular characteristics and markers of advanced clear cell renal cell carcinoma: Pitfalls due to intratumoral heterogeneity and identification of genetic alterations associated with metastasis. Int J Urol. 2020 Jul 8. doi: 10.1111/iju.14302. Epub ahead of print. PMID: 32638444.
Xiao C, Eldridge RC, Beitler JJ, Higgins KA, Chico CE, Felger JC, Wommack EC, Knobf T, Saba NF, Shin DM, Bruner DW, Miller AH. Association Among Glucocorticoid Receptor Sensitivity, Fatigue, and Inflammation in Patients With Head and Neck Cancer. Psychosom Med. 2020 Jun;82(5):508-516. doi: 10.1097/PSY.0000000000000816. PMID: 32515926; PMCID: PMC7905992..
Slavotinek A, Misceo D, Htun S, Mathisen L, Frengen E, Foreman M, Hurtig JE, Enyenihi L, Sterrett MC, Leung SW, Schneidman-Duhovny D, Estrada-Veras J, Duncan JL, Haaxma CA, Kamsteeg EJ, Xia V, Beleford D, Si Y, Douglas G, Treidene HE, van Hoof A, Fasken MB, Corbett AH. Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness. Hum Mol Genet. 2020 Aug 3;29(13):2218-2239. doi: 10.1093/hmg/ddaa108. PMID: 32504085; PMCID: PMC7399534..
Li Z, Sun C, Tao S, Osunkoya AO, Arnold RS, Petros JA, Zu X, Moreno CS. The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression. Transl Oncol. 2020 Apr;13(4):100751. doi: 10.1016/j.tranon.2020.100751. Epub 2020 Mar 18. PMID: 32199273; PMCID: PMC7082632.
Collins CM, Scharer CD, Murphy TJ, Boss JM, Speck SH. Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment. PLoS Pathog. 2020 Apr 30;16(4):e1008438. doi: 10.1371/journal.ppat.1008438. PMID: 32353066; PMCID: PMC7217478.
Grimsley-Myers CM, Isaacson RH, Cadwell CM, Campos J, Hernandes MS, Myers KR, Seo T, Giang W, Griendling KK, Kowalczyk AP. VE-cadherin endocytosis controls vascular integrity and patterning during development. J Cell Biol. 2020 May 4;219(5):e201909081. doi: 10.1083/jcb.201909081. PMID: 32232465; PMCID: PMC7199849.
Hayward SL, Scharer CD, Cartwright EK, Takamura S, Li ZT, Boss JM, Kohlmeier JE. Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells. Nat Immunol. 2020 Mar;21(3):309-320. doi: 10.1038/s41590-019-0584-x. Epub 2020 Jan 17. PMID: 31953534; PMCID: PMC7044042.
Majumder P, Lee JT, Rahmberg AR, Kumar G, Mi T, Scharer CD, Boss JM. A super enhancer controls expression and chromatin architecture within the MHC class II locus. J Exp Med. 2020 Feb 3;217(2):e20190668. doi: 10.1084/jem.20190668. PMID: 31753848; PMCID: PMC7041702.
Farren MR, Sayegh L, Ware MB, Chen HR, Gong J, Liang Y, Krasinskas A, Maithel SK, Zaidi M, Sarmiento JM, Kooby D, Patel P, El-Rayes B, Shaib W, Lesinski GB. Immunologic alterations in the pancreatic cancer microenvironment of patients treated with neoadjuvant chemotherapy and radiotherapy. JCI Insight. 2020 Jan 16;5(1):e130362. doi: 10.1172/jci.insight.130362. PMID: 31830001; PMCID: PMC7030821.
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Eun-Hyung Lee F, Boss JM, Lund FE, Sanz I. Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity. 2020 Jan 14;52(1):203. doi: 10.1016/j.immuni.2019.12.005. Erratum for: Immunity. 2018 Oct 16;49(4):725-739.e6. PMID: 31940271; PMCID: PMC6993874.
Donaldson KJ, Wu WF, Skelton H, Markand S, Ferdous S, Sellers J, Chrenek MA, Gefke I, Kim SM, Rha J, Liao KL, Grossniklaus HE, Jiang Y, Kong J, Boatright JH, Nickerson JM. Analysis of Damage and Wound Healing in the Retinal Pigmented Epithelium. Adv Exp Med Biol. 2019;1185:425-430. doi: 10.1007/978-3-030-27378-1_70. PMID: 31884649; PMCID: PMC7362297.
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