Allosteric regulation of Thioesterase Superfamily Member 1 lipid sensor domain by free fatty acids and lysophosphatidylcholine.Tillman, M.C., Imai, N., Li, Y., Khadka, M., Okafor, C.D., Juneja, P., Adhiyaman, A., Hagen, S.J., Cohen, D.E., Ortlund, E.A., Proceedings of the National Academy of Sciences U S A, 2020, Aug 20;202003877

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.Sanford, J.A., Nogiec, C.D., Lindholm, ME, Adkins, JN, Amar, D, Dasari, S, Drugan, JK, Fernández, F.M., Radom-Aizik, S., Schenk, S., Snyder, M.P., Tracy, R.P., Vanderboom, P., Trappe, S., Walsh M.J., Molecular Transducers of Physical Activity Consortium, Cell, 2020, Jun 25;181(7):1464-1474 **Ortlund, E.A. part of MoTrPAC Consortium. This is the “marker” paper for this consortium.

Lactococcus lactis subsp. cremoris elicits protection against metabolic changes induced by a Western-style diet. Naudin C.R., Maner-Smith K., Owens J.A., Wynn G.M., Robinson B.S., Matthews J.D., April R. Reedy A.R., Luo L., Wolfarth A.A., Darby T.M., Ortlund E.A., Jones, R.M., Gastroenterology, 2020, Feb 4; 28(2):196-205

Acot9 promotes hepatic steatosis by trafficking short chain fatty acids towards lipogenesis and hepatic glucose production. Steensels, S., Qiao, J., Zhang, Y., Maner-Smith, K. M., Kika, N., Holman, C. D., Ivanova, A. A., Corey, K., Ortlund, E. A., Ersoy, B. A., Hepatology, 2020, June 4, Online ahead of print

Alterations in the human plasma lipidome in response to Tularemia vaccination. Maner-Smith, K.M., Goll, J.B., Ford, D.A., Jensen, T.L. Khadka, M., Colucci, J.K., Gelber, C.E., Albert, C.J., Bosinger, S., Franke, S., Natrajan, M., Rouphael, N., Johnson, R., Zanz, P., Anderson, E.J., Hoft, D.F., Mulligan, M., Ortlund, E.A., Vaccines, 2020, Jul 24; 8(3):E414

Structural characterization of life-extending Caenorhabditis Elegans Lipid Binding Protein 8.Tillman, M.C., Khadka, M., Duffy, D., Wang, M.C., Ortlund, E.A., Scientific Reports, 2019; 9, Article number: 9966

The effect of anticoagulants, temperature and time on the human plasma metabolome and lipidome from healthy donors as determined by liquid chromatography-mass spectrometry. Khadka, M., Todor, Andrei, A., Maner-Smith, K.M., Colucci, J.K., Tran, ViLinh, T., Gaul, D.A., Anderson, E., Natrajan, M., Rouphael, N., Mulligan, M.J., McDonald, C., Suthar, M., Li, S., Ortlund, E.A. Biomolecules

Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. Regina Joice Cordy, Rapatbhorn Patrapuvich, Loukia N. Lili, Monica Cabrera-Mora, Jung-Ting Chien, Gregory K. Tharp, Manoj Khadka, Esmeralda V.S. Meyer, Stacey A. Lapp, Chester J. Joyner, AnaPatricia Garcia, Sophia Banton, ViLinh Tran, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, Nattawan Rachaphaew, Suman B. Pakala, Jeremy D. DeBarry, MaHPIC Consortium, Jessica C. Kissinger, Eric A. Ortlund, Steven E. Bosinger, John W. Barnwell, Dean P. Jones, Karan Uppal, Shuzhao Li, Jetsumon Sattabongkot, Alberto Moreno, and Mary R. Galinski. JCI Insight

Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. Regina Joice Cordy, Rapatbhorn Patrapuvich, Loukia N. Lili, Monica Cabrera-Mora, Jung-Ting Chien, Gregory K. Tharp, Manoj Khadka, Esmeralda V.S. Meyer, Stacey A. Lapp, Chester J. Joyner, AnaPatricia Garcia, Sophia Banton, ViLinh Tran, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, Nattawan Rachaphaew, Suman B. Pakala, Jeremy D. DeBarry, MaHPIC Consortium, Jessica C. Kissinger, Eric A. Ortlund, Steven E. Bosinger, John W. Barnwell, Dean P. Jones, Karan Uppal, Shuzhao Li, Jetsumon Sattabongkot, Alberto Moreno, and Mary R. Galinski. JCI Insgiht. 

The effect of anticoagulants, temperature and time on the human plasma metabolome and lipidome from healthy donors as determined by liquid chromatography-mass spectrometry. Khadka, M., Todor, Andrei, A., Maner-Smith, K.M., Colucci, J.K., Tran, ViLinh, T., Gaul, D.A., Anderson, E., Natrajan, M., Rouphael, N., Mulligan, M.J., McDonald, C., Suthar, M., Li, S., Ortlund, E.A., Biomolecules.

Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. Regina Joice Cordy, Rapatbhorn Patrapuvich, Loukia N. Lili, Monica Cabrera-Mora, Jung-Ting Chien, Gregory K. Tharp, Manoj Khadka, Esmeralda V.S. Meyer, Stacey A. Lapp, Chester J. Joyner, AnaPatricia Garcia, Sophia Banton, ViLinh Tran, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, Nattawan Rachaphaew, Suman B. Pakala, Jeremy D. DeBarry, MaHPIC Consortium, Jessica C. Kissinger, Eric A. Ortlund, Steven E. Bosinger, John W. Barnwell, Dean P. Jones, Karan Uppal, Shuzhao Li, Jetsumon Sattabongkot, Alberto Moreno, and Mary R. Galinski. 10.1172/jci.insight.125156

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. Abdul Malik Tyagi, Mingcan Yu, Trevor M. Darby, Chiara Vaccaro, Jau-Yi Li, Joshua A. Owens, Emory Hsu, Jonathan Adams, M. Neale Weitzmann, Rheinallt M. Jones, Roberto Pacifici. Immunity. https://doi.org/10.1016/j.immuni.2018.10.013

High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. Collins JM, Walker DI, Jones DP, Tukvadze N, Liu KH, Tran VT, Uppal K, Frediani JK, Easley KA, Shenvi N, Khadka M, Ortlund EA, Kempker RR, Blumberg HM, Ziegler TR. PLoS One. 2018 Oct 11;13(10):e0205398. doi: 10.1371/journal.pone.0205398. eCollection 2018.

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES. Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011.