February 21, 2017
BIOS 560R Fall Registration
Applied Biostatistics and Bioinformatics in Cancer Research
February 24, 2017
2:00 – 3:50 pm
February 16, 2017
Glycomics Data Club
February 28, 2017
11:30 – 1:00 pm
ROLLINS RESEARCH CENTER 4052 (Biochemistry Conference Room)
O-Glycans in Thrombosis
Professor of Pediatrics
Platelets and a plasma protein von Willebrand factor (VWF) play a critical role in the pathogenesis of thrombotic microangiopathy and the associated thrombocytopenia. Our recent study of VWF and its platelet receptor GPIb-IX suggests the involvement of O-linked glycans in regulating the activities of VWF and GPIb-IX, which lead to thrombocytopenia and pro-thrombotic states under certain circumstances. Our studies illustrate the need for new tools of site-specific modifications of O-glycans.
PIZZA WILL ARRIVE AT 11:30
January 18, 2017
11th Georgia Glycoscience Symposium
April 25, 2017, 8:30 AM - 6 PM
Univeristy of Georgia Complex Carbohydrate Research Center
The focus of this year’s symposium is broadly in the area of the gly- cobiology of immunology and infectious diseases, a research area that has seen remarkable growth over the last decade. We have invited world-class speakers who work in three areas: Microbiome, Virology/ Vaccines, and Host/Pathogen interactions. Through this conference we seek to identify gaps in our understanding, stimulate discussion, and encourage collaboration in this exciting field, in particular between Georgia universities. We will also provide an opportunity for younger scientists (new investigators, graduate students and postdoctoral fel- lows) working in the areas of immunology and infectious diseases to have a forum to discuss their most recent data.
January 17, 2017
Clinical Research Boot Camp 101
February 24, 2017, 7:45 AM - 4 PM
Dobbs Univeristy Center Ballroom
This workshop is designed to provide faculty, staff and post-docs with a comprehensive overview of key clinical research components such as survey design, IRB, database management and other Emory resources. Register by Jan. 27.
January 17, 2017
January 4, 2017
CFAR-Winship Ignites: Strategizing Synergies in Methods and Content
January 19, 2017, 8 AM - 1 PM
Lawrence P. & Ann Estes Klamon Room, 8th Floor, Claudia Nance Rollins Building, Rollins School of Public Health
December 22, 2016
October 26, 2016
Sys/Bio/Info Seminar "Data Preprocessing Pipelines for Mass Spectrometry-Based Metabolomics"
The monthly meeting of Systems Biology and Bioinformatics interest group continues Wednesday, Nov. 2, 2016 at 12 pm, Whitehead Biomedical Research Building, Room 200.
We will feature a seminar by:
Xiuxia Du, PhD (Associate Professor, Bioinformatics and Genomics, UNCC)
- "ADAP-LC and ADAP-GC: Data Preprocessing Pipelines for Mass Spectrometry-Based Metabolomics"
* Sponsored by HERECULES Exposome Research Center (http://emoryhercules.com/).
The meetings are held every first Wednesday of the month, 12 pm. As usual, anyone is welcome to bring a short talk, friends, and questions.
LUNCH WILL BE AVAILABLE
October 24, 2016
October 21, 2016
Glycomics Data Club
October 25, 2016
12:00 – 1:00 pm
SCHOOL OF MEDICINE 190P
Mumps Virus Glycan Receptors: Sickening Sweet, but Low-Carb?
Donald R. Latner, PhD
Center for Disease Control and Prevention, Atlanta, GA
Since 2006, there have been several relatively large outbreaks of mumps virus among highly vaccinated populations in the U.S. The basis for these outbreaks is not clear since there is only one serotype of virus and since there are no parameters of the immune response that are known to reliably assure protection from symptomatic disease. In certain individuals, wildtype mumps virus infection generates poorly protective immunity as evidenced by recurrent symptomatic infections. Similarly, certain individuals who have received two or even three doses of vaccine are susceptible to symptomatic infection. (parotitis, and orchitis in post-pubertal males). In contrast, it is estimated that as many as 30% of immunologically naïve individuals experience no symptoms following wildtype infection, despite evidence of seroconversion. The reasons for this divergence in clinical outcomes are unknown.
Mumps virus requires sialic acid to bind and enter the host cell, and previous reports suggest that mumps binds sialic acid in 2,3, 2,6, and 2,8 linkages, with a neurovirulent strain showing preference for 2,6 binding. A very recent report by Kubota et al (2016 PNAS,113:11579-11584; PMID 27671656) indicates that several mumps strains bind only 2,3 sialic acid in simple unbranched trisaccharides and that binding is inhibited by branched glycan structures. While these studies have used a limited number of glycans, we propose to utilize an extensive library of glycan structures available through the Emory Glycomics Core Facility to more fully characterize mumps receptor binding. We hypothesize that variation in host expression of specific glycan structures may contribute to individual susceptibility to symptomatic infection and to the characteristic pathology.
Latner DR and Hickman CJ (2015) “Remembering Mumps” PLoS Pathog. 2015 May 7;11(5):e1004791.
PIZZA WILL ARRIVE AT 11:30 IN SOM RM 190P
September 28, 2016
The HumanHT-12 v4 Expression BeadChip Kit will be discontinued on December 9th, 2016. Suggested alternatives include the TruSeq Stranded Total RNA, TruSeq RNA Access, and TruSeq Stranded mRNA kits for RNA sequencing. Illumina remains committed to providing you with high-quality support and service during this transition.
May 2, 2016
New website for Human Tissue Procurement Service launched.
The Human Tissue Procurement Service, part of Winship's Cancer Tissue and Pathology Shared Resource, collects, stores, and distributes human tissues to clinicians and researchers. The new website for the service launched last week.