Our services
CRISPR/Cas9 Injections:
Generation of CRISPR-mediated insertions, deletions, point mutations, and gene replacements in mouse embryos SIGMA-partnered core to produce validated CRISPR RNAs Alliance with The Jackson Laboratory mouse model generation services
ES Cell Gene Targeting:
Partnered with Ingenious Targeting Laboratory for gene targeting projects in C57BL/6,129 SvEv, or hybrid ES cells
New rat services
Blastocyst Injection:
Blastocyst injections of ES cell clones and chimera breeding to germline transmission
Speed expansion of your colony
If your project requires many mice of the same age, our speed expansion service can help you. This saves months when compared to traditional breeding approaches and requires only one male mouse. Please contact us for details.
Transgenic Mice Production:
Plasmid or BAC constructs injected on FVB, C57BL/6, or B6D2F1 backgrounds.
Embryo and Sperm Cryopreservation:
Cryopreserve your strain via embryo or sperm freezing with high QC standard, 30 year storage included in the fee.
Line rescue
If sperm quality is low or if your mouse colonies have reproducing issues, we offer strain rescue by IVF, laser-assisted IVF, or ICSI (Intracytoplasmic Sperm Injection). This technique involves injecting a sperm directly into a harvested egg's cytoplasm using a very fine needle. Please contact us for details.
Rederivation:
Rederive any line with your frozen or live sperm, as well as frozen or live embryos
In Vitro Fertilization (IVF):
Importing a new line or expanding a low producing line
Timed Mating and Embryo Collection:
Natural or superovulated pregnancies, includes plug checking and embryo harvesting
Miscellaneous Services:
If it involves mice or ES cells, give us a call. We are here to share our expertise with you.
