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Woolpert KM, Ahern TP, Baurley JW, Maliniak ML, Damkier P, Kjærsgaard A, Collin LJ, Hamilton-Dutoit S, Tramm T, Ejlertsen B, Sørensen HT, Lash TL, Cronin-Fenton DP. Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients. Breast Cancer Res Treat. 2025 Jul;212(2):251-260. doi: 10.1007/s10549-025-07719-1. Epub 2025 May 14. PMID: 40369345; PMCID: PMC12134019.
Jarrell ZR, Lee CM, Lee HY, Kim KH, Lim G, Orr M, Kang SM, Chen Y, Jones DP, Go YM. Cadmium exposure following early-life respiratory syncytial virus infection promotes lung fibrosis through autophagy inhibition. Toxicol Sci. 2025 Jul 1;206(1):123-133. doi: 10.1093/toxsci/kfaf054. PMID: 40268749; PMCID: PMC12198674.
Li Z, Dunlop AL, Sarnat JA, Hüls A, Eick SM, Gaskins A, Chang H, Russell A, Tan Y, Cheng H, Barr DB, Smith AK, Marsit C, Jones DP, Liang D. Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort. Environ Sci Technol. 2025 Jun 10;59(22):10905-10918. doi: 10.1021/acs.est.5c02071. Epub 2025 May 29. PMID: 40440123; PMCID: PMC12164266.
Wiggins KJ, Williams ME, Hicks SL, Padilla-Quirarte HO, Akther J, Randall TD, Boss JM, Scharer CD. EZH2 coordinates memory B-cell programming and recall responses. J Immunol. 2025 May 1;214(5):947-957. doi: 10.1093/jimmun/vkaf004. PMID: 40073167; PMCID: PMC12123212.
Zhang W, Roversi FM, Morris AB, Ortiz K, Zhou G, Hadley A, Zhang X, Silva JAF, Breeden CP, Zhanzak Z, Kissick HT, Larsen CP. Major histocompatibility complex and peptide specificity underpin CD8+ T cell direct alloresponse. Am J Transplant. 2025 May;25(5):916-929. doi: 10.1016/j.ajt.2024.10.011. Epub 2024 Oct 20. PMID: 39433089.
Kline EM, Jernigan JE, Scharer CD, Maurer J, Hicks Sl S, Herrick M MK, Wallings RL, Kelly SD, Chang J, Menees KB, McFarland NR, Boss JM, Tansey MG, Joers V. MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation. bioRxiv [Preprint]. 2025 Mar 4:2024.08.31.610581. doi: 10.1101/2024.08.31.610581. Update in: Sci Rep. 2025 Apr 21;15(1):13705. doi: 10.1038/s41598-025-95679-3. PMID: 40093159; PMCID: PMC11908218.
Khatib TO, Pedro BA, Bombin S, Matsuk VY, Robinson IE, Webster SF, Marcus LJ, Summerbell ER, Tharp GK, Knippler CM, Bagchi P, Kowalski-Muegge J, Johnston HR, Ghalei H, Vertino PM, Mouw JK, Marcus AI. TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion. Cell Rep. 2025 Feb 25;44(2):115315. doi: 10.1016/j.celrep.2025.115315. Epub 2025 Feb 15. PMID: 39955775; PMCID: PMC11951108.
Chen KY, De Giovanni M, Xu Y, An J, Kirthivasan N, Lu E, Jiang K, Brooks S, Ranucci S, Yang J, Kanameishi S, Kabashima K, Brulois K, Bscheider M, Butcher EC, Cyster JG. Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes. Cell. 2025 Feb 20;188(4):1019-1035.e22. doi: 10.1016/j.cell.2024.11.031. Epub 2024 Dec 20. PMID: 39708807; PMCID: PMC11845304.
Zhanzak Z, Johnson AC, Foster P, Cardenas MA, Morris AB, Zhang J, Karadkhele G, Badell IR, Morris AA, Au-Yeung BB, Roversi FM, Silva JAF, Breeden C, Hadley A, Zhang W, Larsen CP, Kissick HT. Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction. Immunity. 2025 Feb 11;58(2):448-464.e6. doi: 10.1016/j.immuni.2025.01.008. Epub 2025 Jan 30. PMID: 39889703.
Li Y, Lim C, Dismuke T, Malawsky DS, Oasa S, Bruce ZC, Offenhäuser C, Baumgartner U, D'Souza RCJ, Edwards SL, French JD, Ock LSH, Nair S, Sivakumaran H, Harris L, Tikunov AP, Hwang D, Alicea Pauneto CDM, Maybury M, Hassall T, Wainwright B, Kesari S, Stein G, Piper M, Johns TG, Sokolsky-Papkov M, Terenius L, Vukojević V, McSwain LF, Gershon TR, Day BW. Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179. Nat Commun. 2025 Feb 4;16(1):1091. doi: 10.1038/s41467-024-54861-3. PMID: 39904981; PMCID: PMC11794477.
Xiao C, Peng G, Conneely KN, Zhao H, Felger JC, Wommack EC, Higgins KA, Shin DM, Saba NF, Bruner DW, Miller AH. DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism. Mol Psychiatry. 2025 Jan;30(1):76-83. doi: 10.1038/s41380-024-02652-z. Epub 2024 Jul 9. PMID: 38977918.
Weinberg J, Liu KH, Lee CM, Crandall WJ, Cuevas AR, Druzak SA, Morgan ET, Jarrell ZR, Ortlund EA, Martin GS, Singer G, Strobel FH, Go YM, Jones DP. Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog. J Biol Chem. 2025 Jan;301(1):108074. doi: 10.1016/j.jbc.2024.108074. Epub 2024 Dec 13. PMID: 39675709; PMCID: PMC11773067.
Lin, F, Lin, S, Wang, J, Sellers, J, Chrenek, M, Nickerson, J, Boatright, J, Geisert, E. An improved method of transducing retinal canglion cells using AAV via transpupillary injection in adult mouse eyes. Molecular Vision. 2025 Jan 12; 31:1-9. http://www.molvis.org/molvis/v31/1.
Elkins C, Ye C, Sivasami P, Mulpur R, Diaz-Saldana PP, Peng A, Xu M, Chiang YP, Moll S, Rivera-Rodriguez DE, Cervantes-Barragan L, Wu T, Au-Yeung BB, Scharer CD, Ford ML, Kissick H, Li C. Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis. Sci Immunol. 2025 Jan 10;10(103):eadl4909. doi: 10.1126/sciimmunol.adl4909. Epub 2025 Jan 10. PMID: 39792637; PMCID: PMC11786953.
Schmidt JA, Hjorth CF, Farkas DK, Damkier P, Feddersen S, Hamilton-Dutoit S, Ejlertsen B, Lash TL, Ahern TP, Cronin-Fenton D. Genetic variants and social benefit receipt in premenopausal women with breast cancer treated with docetaxel: a Danish population-based cohort study. Breast Cancer Res Treat. 2025 Jan;209(1):73-84. doi: 10.1007/s10549-024-07474-9. Epub 2024 Sep 20. PMID: 39302578; PMCID: PMC11785639.
Hicks SL, Scharer CD. Measuring B Cell Chromatin Accessibility by One-Step ATAC-seq. Methods Mol Biol. 2024;2826:55-63. doi: 10.1007/978-1-0716-3950-4_5. PMID: 39017885; PMCID: PMC11789530.
Akdogan-Ozdilek B, George-Alexander LMM, Scharer CD. Epigenomic Profiling of B Cell Subsets by CUT&Tag. Methods Mol Biol. 2024;2826:65-77. doi: 10.1007/978-1-0716-3950-4_6. PMID: 39017886; PMCID: PMC11753148.
Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, Núñez-Ríos DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Hauser MA, Hayes JP, Hemmings SMJ, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL; PGC-PTSD Epigenetics Workgroup; PsychENCODE PTSD Brainomics Project; Traumatic Stress Brain Research Group; Uddin M, Nievergelt CM, Smith AK, Logue MW. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Med. 2024 Dec 18;16(1):147. doi: 10.1186/s13073-024-01417-1. PMID: 39696436; PMCID: PMC11658418.
Rodriguez-Marino N, Royer CJ, Rivera-Rodriguez DE, Seto E, Gracien I, Jones RM, Scharer CD, Gracz AD, Cervantes-Barragan L. Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells. Mucosal Immunol. 2024 Dec;17(6):1301-1313. doi: 10.1016/j.mucimm.2024.08.010. Epub 2024 Sep 5. PMID: 39244090; PMCID: PMC11742265.
Caruso C, Cheng X, Michaud ME, Szafraniec HM, Thomas BE, Fay ME, Mannino RG, Zhang X, Sakurai Y, Li W, Myers DR, Joiner CH, Wood DK, Bhasin M, Graham MD, Lam WA. Less-deformable erythrocyte subpopulations biomechanically induce endothelial inflammation in sickle cell disease. Blood. 2024 Nov 7;144(19):2050-2062. doi: 10.1182/blood.2024024608. PMID: 39178344; PMCID: PMC11561591.
Koo J, Seong CS, Parker RE, Herrera A, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer. Cancer Res. 2024 Nov 15;84(22):3761-3771. doi: 10.1158/0008-5472.CAN-23-2631. PMID: 39207369; PMCID: PMC11565166.
Vattathil SM, Tan SSM, Kim PJ, Bennett DA, Schneider JA, Wingo AP, Wingo TS. Effects of brain microRNAs in cognitive trajectory and Alzheimer's disease. Acta Neuropathol. 2024 Oct 30;148(1):59. doi: 10.1007/s00401-024-02818-7. PMID: 39477879; PMCID: PMC11525270.
Weiss SA, Huang AY, Fung ME, Martinez D, Chen ACY, LaSalle TJ, Miller BC, Scharer CD, Hegde M, Nguyen TH, Rowe JH, Osborn JF, Patterson DG, Sifnugel N, Mei-An Nolan C, Davidson RA, Schwartz MA, Bally APR, Neeld DK, LaFleur MW, Boss JM, Doench JG, Nicholas Haining W, Sharpe AH, Sen DR. Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control. Nat Immunol. 2024 Oct;25(10):1871-1883. doi: 10.1038/s41590-024-01961-3. Epub 2024 Sep 17. PMID: 39289557; PMCID: PMC11528687.
Niu W, Yu S, Li X, Wang Z, Chen R, Michalski C, Jahangiri A, Zohdy Y, Chern JJ, Whitworth TJ, Wang J, Xu J, Zhou Y, Qin Z, Li B, Gambello MJ, Peng J, Wen Z. Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617121. doi: 10.1101/2024.10.07.617121. PMID: 39416123; PMCID: PMC11482767.
Wani AH, Katrinli S, Zhao X, Daskalakis NP, Zannas AS, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fortier C, Geuze E, Hayes JP, Kessler RC, King AP, Koen N, Liberzon I, Lori A, Luykx JJ, Maihofer AX, Milberg W, Miller MW, Mufford MS, Nugent NR, Rauch S, Ressler KJ, Risbrough VB, Rutten BPF, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Nievergelt CM, Logue MW, Smith AK, Uddin M. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts. BMC Med Genomics. 2024 Sep 27;17(1):235. doi: 10.1186/s12920-024-02002-6. PMID: 39334086; PMCID: PMC11429352.
Hood RB, Everson TM, Ford JB, Hauser R, Knight A, Smith AK, Gaskins AJ. Epigenetic age acceleration in follicular fluid and markers of ovarian response among women undergoing IVF. Hum Reprod. 2024 Sep 1;39(9):2003-2009. doi: 10.1093/humrep/deae136. PMID: 38890131; PMCID: PMC11373381.
Jules E, Decker C, Bixler BJ, Ahmed A, Zhou ZC, Arora I, Tafesse H, Dakanay H, Bombin A, Wang E, Ingersoll J, Bifulco K, Frediani JK, Parsons R, Sullivan J, Greenleaf M, Waggoner JJ, Martin GS, Lam WA, Piantadosi A. Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests. medRxiv [Preprint]. 2024 Aug 20:2024.08.19.24311993. doi: 10.1101/2024.08.19.24311993. Update in: Emerg Infect Dis. 2025 May;31(13):39-44. doi: 10.3201/eid3113.241191. PMID: 39228743; PMCID: PMC11370544.
Sobh A, Encinas E, Patel A, Surapaneni G, Bonilla E, Kaestner C, Poullard J, Clerio M, Vasan K, Freeman T, Lv D, Dupéré-Richer D, Riva A, Barwick BG, Zhou D, Boise LH, Mitsiades CS, Kim B, Bennett RL, Chandel NS, Licht JD. NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome. Blood. 2024 Jul 18;144(3):283-295. doi: 10.1182/blood.2023022859. PMID: 38598835; PMCID: PMC11830969.
Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, Núñez-Ríos DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Michael A Hauser, Hayes JP, Hemmings SM, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL; PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group; Uddin M, Nievergelt CM, Smith AK, Logue MW. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts. medRxiv [Preprint]. 2024 Jul 15:2024.07.15.24310422. doi: 10.1101/2024.07.15.24310422. Update in: Genome Med. 2024 Dec 18;16(1):147. doi: 10.1186/s13073-024-01417-1. PMID: 39072012; PMCID: PMC11275670.
Elbasheir A, Katrinli S, Kearney BE, Lanius RA, Harnett NG, Carter SE, Ely TD, Bradley B, Gillespie CF, Stevens JS, Lori A, van Rooij SJH, Powers A, Jovanovic T, Smith AK, Fani N. Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women. JAMA Netw Open. 2024 Jun 3;7(6):e2416588. doi: 10.1001/jamanetworkopen.2024.16588. PMID: 38869898; PMCID: PMC11177169.
Duong HA, Baba K, DeBruyne JP, Davidson AJ, Ehlen C, Powell M, Tosini G. Environmental circadian disruption re-writes liver circadian proteomes. Nat Commun. 2024 Jul 1;15(1):5537. doi: 10.1038/s41467-024-49852-3. PMID: 38956413; PMCID: PMC11220080.
Brockett JS, Manalo T, Zein-Sabatto H, Lee J, Fang J, Chu P, Feng H, Patil D, Davidson P, Ogan K, Master VA, Pattaras JG, Roberts DL, Bergquist SH, Reyna MA, Petros JA, Lerit DA, Arnold RS. A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila. Genetics. 2024 Apr 3;226(4):iyae015. doi: 10.1093/genetics/iyae015. PMID: 38290049; PMCID: PMC10990431.
Yoon SB, Chen L, Robinson IE, Khatib TO, Arthur RA, Claussen H, Zohbi NM, Wu H, Mouw JK, Marcus AI. Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332. J Cell Biol. 2024 Jun 3;223(6):e202308080. doi: 10.1083/jcb.202308080. Epub 2024 Mar 29. PMID: 38551497; PMCID: PMC10982113.
Damhorst GL, Fujita AW, Fitts E, Szabo B, Bowers HB, Sabino C, Ahmed A, Wang E, Piantadosi A, McLendon K, Sullivan J, Greenleaf M, McCaslin D, Palmore M, Anderson AM, Aldred B, Gunthel C, Martin GS, Colasanti JA, Lam WA, Bassit L, Rao A, Sheth AN, Titanji BK. Multisite Mpox Infection and Viral Dynamics Among Persons With HIV in Metro Atlanta. J Infect Dis. 2024 Mar 26;229(Supplement_2):S213-S218. doi: 10.1093/infdis/jiad530. PMID: 38019187; PMCID: PMC10965212.
Bai J, Eldridge R, Houser M, Martin M, Powell C, Sutton KS, Noh HI, Wu Y, Olson T, Konstantinidis KT, Bruner DW. Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy. J Transl Med. 2024 Mar 9;22(1):256. doi: 10.1186/s12967-024-05066-1. PMID: 38461265; PMCID: PMC10924342.
Oami T, Abtahi S, Shimazui T, Chen CW, Sweat YY, Liang Z, Burd EM, Farris AB, Roland JT, Tsukita S, Ford ML, Turner JR, Coopersmith CM. Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2217877121. doi: 10.1073/pnas.2217877121. Epub 2024 Feb 27. PMID: 38412124; PMCID: PMC10927519.
Tang Z, Gaskins AJ, Hood RB, Ford JB, Hauser R, Smith AK, Everson TM. Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproduction. Sci Rep. 2024 Feb 29;14(1):5009. doi: 10.1038/s41598-024-54957-2. PMID: 38424222; PMCID: PMC10904848.
Wani A, Katrinli S, Zhao X, Daskalakis N, Zannas A, Aiello A, Baker D, Boks M, Brick L, Chen CY, Dalvie S, Fortier C, Geuze E, Hayes J, Kessler R, King A, Koen N, Liberzon I, Lori A, Luykx J, Maihofer A, Milberg W, Miller M, Mufford M, Nugent N, Rauch S, Ressler K, Risbrough V, Rutten B, Stein D, Stein M, Ursano R, Verfaellie M, Ware E, Wildman D, Wolf E, Nievergelt C, Logue M, Smith A, Uddin M, Vermetten E, Vinkers C. Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts. Res Sq [Preprint]. 2024 Feb 15:rs.3.rs-3952163. doi: 10.21203/rs.3.rs-3952163/v1. Update in: BMC Med Genomics. 2024 Sep 27;17(1):235. doi: 10.1186/s12920-024-02002-6. PMID: 38410438; PMCID: PMC10896387.
Eggert J, Zinzow-Kramer WM, Hu Y, Kolawole EM, Tsai YL, Weiss A, Evavold BD, Salaita K, Scharer CD, Au-Yeung BB. Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling. Sci Signal. 2024 Feb 6;17(822):eadh0439. doi: 10.1126/scisignal.adh0439. Epub 2024 Feb 6. PMID: 38319998; PMCID: PMC10897907.
Hong L, Williams NL, Jaffe M, Shields CE, Haynes KA. Synthetic Reader-Actuators Targeted to Polycomb-Silenced Genes Block Triple-Negative Breast Cancer Proliferation and Invasion. GEN Biotechnol. 2023 Aug 1;2(4):301-316. doi: 10.1089/genbio.2023.0020. Epub 2023 Aug 17. PMID: 37928406; PMCID: PMC10623628.
Sivasami P, Elkins C, Diaz-Saldana PP, Goss K, Peng A, Hamersky M 4th, Bae J, Xu M, Pollack BP, Horwitz EM, Scharer CD, Seldin L, Li C. Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation. Immunity. 2023 Aug 8;56(8):1844-1861.e6. doi: 10.1016/j.immuni.2023.06.021. Epub 2023 Jul 20. PMID: 37478855; PMCID: PMC10527179.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544941. doi: 10.1101/2023.06.14.544941. PMID: 37398244; PMCID: PMC10312689.
Zuo Z, Kania AK, Patterson DG, Hicks SL, Maurer J, Gupta M, Boss JM, Scharer CD. CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation. Heliyon. 2023 Jun 21;9(6):e17527. doi: 10.1016/j.heliyon.2023.e17527. PMID: 37416674; PMCID: PMC10320122.
Nguyen PV, Carmola LR, Wang E, Bassit L, Rao A, Greenleaf M, Sullivan JA, Martin GS, Lam WA, Waggoner JJ, Piantadosi A. SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 antigen self tests. J Clin Virol. 2023 May;162:105426. doi: 10.1016/j.jcv.2023.105426. Epub 2023 Mar 24. PMID: 37028004; PMCID: PMC10036152.
Geitgey DK, Lee M, Cottrill KA, Jaffe M, Pilcher W, Bhasin S, Randall J, Ross AJ, Salemi M, Castillo-Castrejon M, Kilgore MB, Brown AC, Boss JM, Johnston R, Fitzpatrick AM, Kemp ML, English R, Weaver E, Bagchi P, Walsh R, Scharer CD, Bhasin M, Chandler JD, Haynes KA, Wellberg EA, Henry CJ. The 'omics of obesity in B-cell acute lymphoblastic leukemia. J Natl Cancer Inst Monogr. 2023 May 4;2023(61):12-29. doi: 10.1093/jncimonographs/lgad014. PMID: 37139973; PMCID: PMC10157791.
Nellore A, Zumaquero E, Scharer CD, Fucile CF, Tipton CM, King RG, Mi T, Mousseau B, Bradley JE, Zhou F, Mutneja S, Goepfert PA, Boss JM, Randall TD, Sanz I, Rosenberg AF, Lund FE. A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans. Immunity. 2023 Apr 11;56(4):847-863.e8. doi: 10.1016/j.immuni.2023.03.001. Epub 2023 Mar 22. PMID: 36958335; PMCID: PMC10113805.
Rose JR, Akdogan-Ozdilek B, Rahmberg AR, Powell MD, Hicks SL, Scharer CD, Boss JM. Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential. Commun Biol. 2023 Apr 3;6(1):363. doi: 10.1038/s42003-023-04747-9. PMID: 37012418; PMCID: PMC10070634.
Ware MB, Phillips M, McQuinn C, Zaidi MY, Knochelmann HM, Greene E, Robinson B, Herting CJ, Mace TA, Chen Z, Zhang C, Farren MR, Ruggieri AN, Bowers JS, Shakya R, Farris AB, Young G, Carson WE 3rd, El-Rayes B, Paulos CM, Lesinski GB. Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell- and CXCR3-dependent manner. JCI Insight. 2023 Apr 24;8(8):e155006. doi: 10.1172/jci.insight.155006. PMID: 36881480; PMCID: PMC10243806.
Qian DC, Ulrich BC, Peng G, Zhao H, Conneely KN, Miller AH, Bruner DW, Eldridge RC, Wommack EC, Higgins KA, Shin DM, Saba NF, Smith AK, Burtness B, Park HS, Stokes WA, Beitler JJ, Xiao C. Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood. Int J Radiat Oncol Biol Phys. 2023 Apr 1;115(5):1217-1228. doi: 10.1016/j.ijrobp.2022.11.009. Epub 2022 Nov 21. PMID: 36410685.
Richardson BN, Noh HI, Webster CI, Zhang W, Kim S, Yang I, Bai J. Oral Microbiome, Mental Health, and Sleep Outcomes During the COVID-19 Pandemic: An Observational Study in Chinese and Korean American Immigrants. OMICS. 2023 Apr;27(4):180-190. doi: 10.1089/omi.2022.0182. Epub 2023 Mar 22. PMID: 36946910; PMCID: PMC10122216.
Zhu L, Zhao Y, Liu T, Chen M, Qian WP, Jiang B, Barwick BG, Zhang L, Styblo TM, Li X, Yang L. Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy. ACS Nano. 2022 Nov 22;16(11):18708-18728. doi: 10.1021/acsnano.2c07440. Epub 2022 Oct 18. PMID: 36256454; PMCID: PMC9764083.
Lobby JL, Uddbäck I, Scharer CD, Mi T, Boss JM, Thomsen AR, Christensen JP, Kohlmeier JE. Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8+ T Cells. J Immunol. 2022 Nov 1;209(9):1778-1787. doi: 10.4049/jimmunol.2200082. Epub 2022 Sep 26. PMID: 36162870; PMCID: PMC9588742.
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Zinzow-Kramer WM, Kolawole EM, Eggert J, Evavold BD, Scharer CD, Au-Yeung BB. Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4+ T Cells. Immunohorizons. 2022 Sep 13;6(9):671-683. doi: 10.4049/immunohorizons.2200051. PMID: 36100367.
Zhou C, Uluisik R, Rowley JW, David C, Jones CL, Scharer CD, Noetzli L, Fisher MH, Kirkpatrick GD, Bark K, Boss JM, Henry CJ, Pietras EM, Di Paola J, Porter CC. Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Exp Hematol. 2022 Aug-Sep;112-113:24-34. doi: 10.1016/j.exphem.2022.06.002. Epub 2022 Jul 6. PMID: 35803545; PMCID: PMC9885892.
Lee M, Geitgey DK, Hamilton JAG, Boss JM, Scharer CD, Spangle JM, Haynes KA, Henry CJ. Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Front Cell Dev Biol. 2022 Aug 19;10:909557. doi: 10.3389/fcell.2022.909557. PMID: 36060800; PMCID: PMC9438935.
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Bekhbat M, Ulukaya GB, Bhasin MK, Felger JC, Miller AH. Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen. Neurobiol Stress. 2022 May 24;19:100462. doi: 10.1016/j.ynstr.2022.100462. PMID: 35655933; PMCID: PMC9152104.
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Liu M, Starenki D, Scharer CD, Silva-Sanchez A, Molina PA, Pollock JS, Cooper SJ, Arend RC, Rosenberg AF, Randall TD, Meza-Perez S. Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features. Cancer Immunol Res. 2022 May 3;10(5):641-655. doi: 10.1158/2326-6066.CIR-21-0880. PMID: 35263766; PMCID: PMC9064962.
Dale GA, Wilkins DJ, Rowley J, Scharer CD, Tipton CM, Hom J, Boss JM, Corces V, Sanz I, Jacob J. Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. J Immunol. 2022 May 1;208(9):2141-2153. doi: 10.4049/jimmunol.2100434. Epub 2022 Apr 13. PMID: 35418472; PMCID: PMC9047068.
Kania AK, Price MJ, George-Alexander LE, Patterson DG, Hicks SL, Scharer CD, Boss JM. H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. J Immunol. 2022 Apr 15;208(8):1873-1885. doi: 10.4049/jimmunol.2100948. Epub 2022 Mar 28. PMID: 35346967; PMCID: PMC9012698.
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Lee M, Hamilton JAG, Talekar GR, Ross AJ, Michael L, Rupji M, Dwivedi B, Raikar SS, Boss J, Scharer CD, Graham DK, DeRyckere D, Porter CC, Henry CJ. Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia. Nat Commun. 2022 Mar 3;13(1):1157. doi: 10.1038/s41467-022-28839-y. PMID: 35241678; PMCID: PMC8894417.
Zhang H, Dammer EB, Duong DM, Danelia D, Seyfried NT, Yu DS. Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates. Sci Rep. 2022 Mar 9;12(1):3822. doi: 10.1038/s41598-022-06793-5. PMID: 35264593; PMCID: PMC8907344.
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Kania AK, Guo M, Scharer CD, Boss JM. Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation. Immunohorizons. 2021 Dec 8;5(12):918-930. doi: 10.4049/immunohorizons.2000087. PMID: 34880105; PMCID: PMC10197425.
Patterson DG, Kania AK, Price MJ, Rose JR, Scharer CD, Boss JM. An IRF4-MYC-mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo. J Immunol. 2021 Oct 1;207(7):1798-1811. doi: 10.4049/jimmunol.2100440. Epub 2021 Sep 1. PMID: 34470852; PMCID: PMC8455452.
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Price MJ, Scharer CD, Kania AK, Randall TD, Boss JM. Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation. J Immunol. 2021 Apr 1;206(7):1493-1504. doi: 10.4049/jimmunol.2000551. Epub 2021 Feb 24. PMID: 33627377; PMCID: PMC7988296.
Andueza A, Kumar S, Kim J, Kang DW, Mumme HL, Perez JI, Villa-Roel N, Jo H. Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study. Cell Rep. 2020 Dec 15;33(11):108491. doi: 10.1016/j.celrep.2020.108491. PMID: 33326796; PMCID: PMC7801938.
Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. J Biol Chem. 2021 Jan-Jun;296:100024. doi: 10.1074/jbc.RA120.016009. Epub 2020 Nov 22. PMID: 33410399; PMCID: PMC7949046.
Vigneswaran K, Boyd NH, Oh SY, Lallani S, Boucher A, Neill SG, Olson JJ, Read RD. YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma. Clin Cancer Res. 2021 Mar 1;27(5):1553-1569. doi: 10.1158/1078-0432.CCR-20-0018. Epub 2020 Nov 10. PMID: 33172899.
Scharer CD, Fortner KA, Dragon JA, Tighe S, Boss JM, Budd RC. Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice. Immunohorizons. 2020 Oct 23;4(10):679-687. doi: 10.4049/immunohorizons.2000078. PMID: 33097564; PMCID: PMC8141279.
Babiker A, Bradley HL, Stittleburg VD, Ingersoll JM, Key A, Kraft CS, Waggoner JJ, Piantadosi A. Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19. J Clin Microbiol. 2020 Oct 16:JCM.02142-20. doi: 10.1128/JCM.02142-20. Epub ahead of print. PMID: 33067271.
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Inglis GAS, Zhou Y, Patterson DG, Scharer CD, Han Y, Boss JM, Wen Z, Escayg A. Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons. Hum Mol Genet. 2020 Aug 29;29(15):2579-2595. doi: 10.1093/hmg/ddaa150. PMID: 32794569; PMCID: PMC7471504.
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Li Z, Sun C, Tao S, Osunkoya AO, Arnold RS, Petros JA, Zu X, Moreno CS. The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression. Transl Oncol. 2020 Apr;13(4):100751. doi: 10.1016/j.tranon.2020.100751. Epub 2020 Mar 18. PMID: 32199273; PMCID: PMC7082632.
Collins CM, Scharer CD, Murphy TJ, Boss JM, Speck SH. Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment. PLoS Pathog. 2020 Apr 30;16(4):e1008438. doi: 10.1371/journal.ppat.1008438. PMID: 32353066; PMCID: PMC7217478.
Grimsley-Myers CM, Isaacson RH, Cadwell CM, Campos J, Hernandes MS, Myers KR, Seo T, Giang W, Griendling KK, Kowalczyk AP. VE-cadherin endocytosis controls vascular integrity and patterning during development. J Cell Biol. 2020 May 4;219(5):e201909081. doi: 10.1083/jcb.201909081. PMID: 32232465; PMCID: PMC7199849.
Hayward SL, Scharer CD, Cartwright EK, Takamura S, Li ZT, Boss JM, Kohlmeier JE. Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells. Nat Immunol. 2020 Mar;21(3):309-320. doi: 10.1038/s41590-019-0584-x. Epub 2020 Jan 17. PMID: 31953534; PMCID: PMC7044042.
Majumder P, Lee JT, Rahmberg AR, Kumar G, Mi T, Scharer CD, Boss JM. A super enhancer controls expression and chromatin architecture within the MHC class II locus. J Exp Med. 2020 Feb 3;217(2):e20190668. doi: 10.1084/jem.20190668. PMID: 31753848; PMCID: PMC7041702.
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Ferdous S, Grossniklaus HE, Boatright JH, Nickerson JM. Characterization of LSD1 Expression Within the Murine Eye. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4619-4631. doi: 10.1167/iovs.19-26728. PMID: 31675426; PMCID: PMC6827424.
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Haines RR, Scharer CD, Lobby JL, Boss JM. LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development. J Immunol. 2019 Oct 1;203(7):1867-1881. doi: 10.4049/jimmunol.1900654. Epub 2019 Sep 6. PMID: 31492745; PMCID: PMC6761012.
Price MJ, Hicks SL, Bradley JE, Randall TD, Boss JM, Scharer CD. IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes. J Immunol. 2019 Oct 15;203(8):2121-2129. doi: 10.4049/jimmunol.1900285. Epub 2019 Sep 9. PMID: 31501259; PMCID: PMC6783370.
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