Selected Publications

  1. Jin L, Li D, Alesi Gina N, Fan J, Kang H-B, Lu Z, Boggon Titus J, Jin P, Yi H, Wright Elizabeth R, Duong D, Seyfried Nicholas T, Egnatchik R, DeBerardinis Ralph J, Magliocca Kelly R, He C, Arellano Martha L, Khoury Hanna J, Shin Dong M, Khuri Fadlo R, Kang S. Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth. Cancer Cell.27(2):257-70. doi: 10.1016/j.ccell.2014.12.006.
  2. Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(41):16562-7. Epub 2013/09/12. doi: 10.1073/pnas.1310249110. PubMed PMID: 24023061; PubMed Central PMCID: PMCPmc3799305.
  3. Dammer EB, Duong DM, Diner I, Gearing M, Feng Y, Lah JJ, Levey AI, Seyfried NT. Neuron enriched nuclear proteome isolated from human brain. Journal of proteome research. 2013;12(7):3193-206. Epub 2013/06/19. doi: 10.1021/pr400246t. PubMed PMID: 23768213; PubMed Central PMCID: PMCPmc3734798.
  4. Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT. Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination. PLoS ONE. 2012;7(6):e38658. doi: 10.1371/journal.pone.0038658.
  5. Dammer EB, Lee AK, Duong DM, Gearing M, Lah JJ, Levey A, Seyfried NT. Quantitative Phosphoproteomics of Alzheimer’s Disease Reveals Crosstalk between Kinases and Small Heat Shock Proteins. Proteomics. 2015 Jan;15(2-3):508-19. doi:  10.1002/pmic.201400189. Epub 2014 Dec 17. PubMed PMID: 25332170; PubMed Central PMCID: PMC4404162
  6. Zhou J, Jones DR, Duong DM, Levey AI, Lah JJ, Peng J. Proteomic analysis of postsynaptic density in Alzheimer's Disease. Clinica Chimica Acta. 2013;420(0):62-8. doi:
  7. Gozal YM, Cheng D, Duong DM, Lah JJ, Levey AI, Peng J. Merger of laser capture microdissection and mass spectrometry: a window into the amyloid plaque proteome. Methods Enzymol. 2006;412:77-93. PubMed PMID: 17046653.
  8. Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ. U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21. Molecular neurodegeneration. 2014;9:15. Epub 2014/04/30. doi: 10.1186/1750-1326-9-15. PubMed PMID: 24773620; PubMed Central PMCID: PMCPmc4022210.
  9. Kallappagoudar S, Dammer EB, Duong DM, Seyfried NT, Lucchesi JC. Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16. Proteomics. 2013;13(10-11):1687-91. Epub 2013/04/05. doi: 10.1002/pmic.201300025. PubMed PMID: 23554095; PubMed Central PMCID: PMCPmc3771349.
  10. Herskowitz JH, Feng Y, Mattheyses AL, Hales CM, Higginbotham LA, Duong DM, Montine TJ, Troncoso JC, Thambisetty M, Seyfried NT, Levey AI, Lah JJ. Pharmacologic inhibition of ROCK2 suppresses amyloid-beta production in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(49):19086-98. Epub 2013/12/07. doi: 10.1523/jneurosci.2508-13.2013. PubMed PMID: 24305806; PubMed Central PMCID: PMCPmc3850036.
  11. Go YM, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP. Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems. Molecular & cellular proteomics : MCP. 2013;12(11):3285-96. Epub 2013/08/16. doi: 10.1074/mcp.M113.030437. PubMed PMID: 23946468; PubMed Central PMCID: PMCPmc3820939.
  12. Donovan LE, Dammer EB, Duong DM, Hanfelt JJ, Levey AI, Seyfried NT, Lah JJ. Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease. Alzheimer's research & therapy. 2013;5(3):32. Epub 2013/06/15. doi: 10.1186/alzrt186. PubMed PMID: 23764030; PubMed Central PMCID: PMCPmc4054949.
  13. Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees HD, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey AI, Peng J. Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. Journal of proteome research. 2012;11(5):2721-38. Epub 2012/03/16. doi: 10.1021/pr2010814. PubMed PMID: 22416763; PubMed Central PMCID: PMCPmc3357000.
  14. Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT. Asparaginyl endopeptidase cleaves TDP-43 in brain. Proteomics. 2012;12(15-16):2455-63. Epub 2012/06/22. doi: 10.1002/pmic.201200006. PubMed PMID: 22718532; PubMed Central PMCID: PMCPmc3787696.
  15. Donovan LE, Higginbotham L, Dammer EB, Gearing M, Rees HD, Xia Q, Duong DM, Seyfried NT, Lah JJ, Levey AI. Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease. Proteomics Clinical applications. 2012;6(3-4):201-11. Epub 2012/04/26. doi: 10.1002/prca.201100068. PubMed PMID: 22532456; PubMed Central PMCID: PMCPmc3338199.
  16. Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ. Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. The Journal of biological chemistry. 2011;286(8):6117-27. Epub 2010/12/15. doi: 10.1074/jbc.M110.167239. PubMed PMID: 21147781; PubMed Central PMCID: PMCPmc3057792.
  17. Franco M, Seyfried NT, Brand AH, Peng J, Mayor U. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Molecular & cellular proteomics : MCP. 2011;10(5):M110 002188. doi: 10.1074/mcp.M110.002188. PubMed PMID: 20861518; PubMed Central PMCID: PMC3098581.
  18. Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, Gearing M, Rees H, Lah JJ, Levey AI, Rush J, Peng J. Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. The Journal of biological chemistry. 2011;286(12):10457-65. Epub 2011/02/01. doi: 10.1074/jbc.M110.149633. PubMed PMID: 21278249; PubMed Central PMCID: PMCPmc3060499.
  19. Seyfried NT, Gozal YM, Dammer EB, Xia Q, Duong DM, Cheng D, Lah JJ, Levey AI, Peng J. Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains. Molecular & cellular proteomics : MCP. 2010;9(4):705-18. Epub 2010/01/06. doi: 10.1074/mcp.M800390-MCP200. PubMed PMID: 20047951; PubMed Central PMCID: PMCPmc2860236.
  20. Herskowitz JH, Seyfried NT, Duong DM, Xia Q, Rees HD, Gearing M, Peng J, Lah JJ, Levey AI. Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. Journal of proteome research. 2010;9(12):6368-79. Epub 2010/10/05. doi: 10.1021/pr100666c. PubMed PMID: 20886841; PubMed Central PMCID: PMCPmc2997170.
  21. Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J, Hochstrasser M, Finley D, Peng J. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell. 2009;137(1):133-45. Epub 2009/04/07. doi: 10.1016/j.cell.2009.01.041. PubMed PMID: 19345192; PubMed Central PMCID: PMCPmc2668214.
  22. Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J. Systematic approach for validating the ubiquitinated proteome. Analytical chemistry. 2008;80(11):4161-9. Epub 2008/04/25. doi: 10.1021/ac702516a. PubMed PMID: 18433149; PubMed Central PMCID: PMCPmc2673951.
  23. Gozal YM, Duong DM, Gearing M, Cheng D, Hanfelt J, Funderburk C, Peng J, Lah J, Levey A. Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimers disease. Journal of Proteome Research. 2009. doi: 10.1021/pr900474t.
  24. Gozal YM, Seyfried NT, Gearing M, Glass JD, Heilman CJ, Wuu J, Duong DM, Cheng D, Xia Q, Rees HD, Fritz JJ, Cooper DS, Peng J, Levey AI, Lah JJ. Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration. Molecular neurodegeneration. 2011;6:82. Epub 2011/12/01. doi: 10.1186/1750-1326-6-82. PubMed PMID: 22126117; PubMed Central PMCID: PMCPmc3259087.
  25. Go Y-M, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP. Selective Targeting of the Cysteine Proteome by Thioredoxin and Glutathione Redox Systems. Molecular & cellular proteomics : MCP. 2013;12(11):3285-96. doi: 10.1074/mcp.M113.030437. PubMed PMID: PMC3820939.