Temporal dynamics of the multi-omic response to endurance exercise training. MoTrPAC Study Group; Lead Analysts; MoTrPAC Study Group. Nature. 2024 May;629(8010):174-183. doi: 10.1038/s41586-023-06877-w. Epub 2024 May 1. PMID: 38693412 Free PMC article.
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock KL, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman MF, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman BC, Fernández FM, Goodyear LJ, Hevener AL, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S; MoTrPAC Study Group. Nat Metab. 2024 May;6(5):963-979. doi: 10.1038/s42255-023-00959-9. Epub 2024 May 1. PMID: 38693320 Free PMC article.
The impact of exercise on gene regulation in association with complex trait genetics. Vetr NG, Gay NR; MoTrPAC Study Group; Montgomery SB. Nat Commun. 2024 May 1;15(1):3346. doi: 10.1038/s41467-024-45966-w. PMID: 38693125 Free PMC article.
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. Nature. 2024 Dec;636(8043):E9. doi: 10.1038/s41586-024-08434-5. PMID: 39633058 No abstract available.
Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease. Huneault HE, Chen CY, Cohen CC, Liu X, Jarrell ZR, He Z, DeSantos KE, Welsh JA, Maner-Smith KM, Ortlund EA, Schwimmer JB, Vos MB. Metabolites. 2024 Mar 28;14(4):191. doi: 10.3390/metabo14040191. PMID: 38668319 Free PMC article.
Integrative brain omics approach reveals key role for sn-1 lysophosphatidylethanolamine in Alzheimer's dementia. Ortlund E, Chen CY, Maner-Smith K, Khadka M, Ahn J, Gulbin X, Ivanova A, Dammer E, Seyfried N, Bennett D, Hajjar I. Res Sq [Preprint]. 2024 Feb 27:rs.3.rs-3973736. doi: 10.21203/rs.3.rs-3973736/v1. PMID: 38464293 Free PMC article. Preprint.
Improving Functional Muscle Regeneration in Volumetric Muscle Loss Injuries by Shifting the Balance of Inflammatory and Pro-Resolving Lipid Mediators. Turner TC, Pittman FS, Zhang H, Hymel LA, Zheng T, Behara M, Anderson SE, Harrer JA, Link KA, Ahammed MA, Maner-Smith K, Liu X, Yin X, Lim HS, Spite M, Qiu P, García AJ, Mortensen LJ, Jang YC, Willett NJ, Botchwey EA. bioRxiv [Preprint]. 2024 Sep 12:2024.09.06.611741. doi: 10.1101/2024.09.06.611741. PMID: 39314313 Free PMC article. Preprint.
Linoleic acid blunts early osteoblast differentiation and impairs oxidative phosphorylation in vitro. Nesbeth PC, Ziegler TR, Tripathi AK, Dabeer S, Weiss D, Hao L, Smith MR, Jones DP, Maner-Smith KM, Tu CL, Chang W, Weitzmann MN, Alvarez JA. Prostaglandins Leukot Essent Fatty Acids. 2024 Feb;201:102617. doi: 10.1016/j.plefa.2024.102617. Epub 2024 May 9. PMID: 38788347
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose. Rostad CA, Yildirim I, Kao C, Yi J, Kamidani S, Peters E, Stephens K, Gibson T, Hsiao HM, Singh K, Spearman P, McCracken C, Agbakoba V, Tomashek KM, Goll JB, Gelber CE, Johnson RA, Lee S, Maner-Smith K, Bosinger S, Ortlund EA, Chen X, Anderson LJ, Wrammert J, Suthar M, Rouphael N, Anderson EJ. NPJ Vaccines. 2024 Dec 23;9(1):255. doi: 10.1038/s41541-024-01042-4. PMID: 39715748 Free PMC article
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19. Druzak S, Iffrig E, Roberts BR, Zhang T, Fibben KS, Sakurai Y, Verkerke HP, Rostad CA, Chahroudi A, Schneider F, Wong AKH, Roberts AM, Chandler JD, Kim SO, Mosunjac M, Mosunjac M, Geller R, Albizua I, Stowell SR, Arthur CM, Anderson EJ, Ivanova AA, Ahn J, Liu X, Maner-Smith K, Bowen T, Paiardini M, Bosinger SE, Roback JD, Kulpa DA, Silvestri G, Lam WA, Ortlund EA, Maier CL. Nat Commun. 2023 Apr 4;14(1):1638. doi: 10.1038/s41467-023-37269-3. PMID: 37015925 Free PMC article.
Circulating short chain fatty acids and fatigue in patients with head and neck cancer: A longitudinal prospective study. Xiao C, Fedirko V, Claussen H, Richard Johnston H, Peng G, Paul S, Maner-Smith KM, Higgins KA, Shin DM, Saba NF, Wommack EC, Bruner DW, Miller AH. Brain Behav Immun. 2023 Oct;113:432-443. doi: 10.1016/j.bbi.2023.07.025. Epub 2023 Aug 4. PMID: 37543249 Free PMC article.
Metabolome × Microbiome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys. Cohen CC, Huneault H, Accardi CJ, Jones DP, Liu K, Maner-Smith KM, Song M, Welsh JA, Ugalde-Nicalo PA, Schwimmer JB, Vos MB. Metabolites. 2023 Mar 8;13(3):401. doi: 10.3390/metabo13030401. PMID: 36984841 Free PMC article.
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16. PMID: 36385529 Free PMC article.
African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids. Maner-Smith KM, Ferranti E, Dunlop A, Corwin E, Ortlund EA. Nutrients. 2022 Dec 28;15(1):140. doi: 10.3390/nu15010140. PMID: 36615797 Free PMC article.
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen. Liu KH, Owens JA, Saeedi B, Cohen CE, Bellissimo MP, Naudin C, Darby T, Druzak S, Maner-Smith K, Orr M, Hu X, Fernandes J, Camacho MC, Hunter-Chang S, VanInsberghe D, Ma C, Ganesh T, Yeligar SM, Uppal K, Go YM, Alvarez JA, Vos MB, Ziegler TR, Woodworth MH, Kraft CS, Jones RM, Ortlund E, Neish AS, Jones DP. Nat Metab. 2021 Dec;3(12):1694-1705. doi: 10.1038/s42255-021-00502-8. Epub 2021 Dec 20. PMID: 34931082 Free PMC article.
TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis. Collins JM, Jones DP, Sharma A, Khadka M, Liu KH, Kempker RR, Prideaux B, Maner-Smith K, Tukvadze N, Shah NS, Brust JCM, Sékaly RP, Gandhi NR, Blumberg HM, Ortlund EA, Ziegler TR. PLoS Pathog. 2021 Sep 24;17(9):e1009941. doi: 10.1371/journal.ppat.1009941. eCollection 2021 Sep. PMID: 34559866 Free PMC article.
Allosteric regulation of Thioesterase Superfamily Member 1 lipid sensor domain by free fatty acids and lysophosphatidylcholine.Tillman, M.C., Imai, N., Li, Y., Khadka, M., Okafor, C.D., Juneja, P., Adhiyaman, A., Hagen, S.J., Cohen, D.E., Ortlund, E.A., Proceedings of the National Academy of Sciences U S A, 2020, Aug 20;202003877
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Sanford, J.A., Nogiec, C.D., Lindholm, ME, Adkins, JN, Amar, D, Dasari, S, Drugan, JK, Fernández, F.M., Radom-Aizik, S., Schenk, S., Snyder, M.P., Tracy, R.P., Vanderboom, P., Trappe, S., Walsh M.J., Molecular Transducers of Physical Activity Consortium, Cell, 2020, Jun 25;181(7):1464-1474 **Ortlund, E.A. part of MoTrPAC Consortium. This is the “marker” paper for this consortium.
Lactococcus lactis subsp. cremoris elicits protection against metabolic changes induced by a Western-style diet. Naudin C.R., Maner-Smith K., Owens J.A., Wynn G.M., Robinson B.S., Matthews J.D., April R. Reedy A.R., Luo L., Wolfarth A.A., Darby T.M., Ortlund E.A., Jones, R.M., Gastroenterology, 2020, Feb 4; 28(2):196-205
Acot9 promotes hepatic steatosis by trafficking short chain fatty acids towards lipogenesis and hepatic glucose production. Steensels, S., Qiao, J., Zhang, Y., Maner-Smith, K. M., Kika, N., Holman, C. D., Ivanova, A. A., Corey, K., Ortlund, E. A., Ersoy, B. A., Hepatology, 2020, June 4, Online ahead of print
Alterations in the human plasma lipidome in response to Tularemia vaccination. Maner-Smith, K.M., Goll, J.B., Ford, D.A., Jensen, T.L. Khadka, M., Colucci, J.K., Gelber, C.E., Albert, C.J., Bosinger, S., Franke, S., Natrajan, M., Rouphael, N., Johnson, R., Zanz, P., Anderson, E.J., Hoft, D.F., Mulligan, M., Ortlund, E.A., Vaccines, 2020, Jul 24; 8(3):E414. doi: 10.3390/vaccines8030414. PMID: 32722213 Free PMC article.
Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver. Steensels S, Qiao J, Zhang Y, Maner-Smith KM, Kika N, Holman CD, Corey KE, Bracken WC, Ortlund EA, Ersoy BA. Hepatology. 2020 Sep;72(3):857-872. doi: 10.1002/hep.31409. PMID: 32498134
Hepatic fat is a stronger correlate of key clinical and molecular abnormalities than visceral and abdominal subcutaneous fat in youth. Cioffi CE, Narayan KMV, Liu K, Uppal K, Jones DP, Tran V, Yu T, Alvarez JA, Bellissimo MP, Maner-Smith KM, Pierpoint B, Caprio S, Santoro N, Vos MB. BMJ Open Diabetes Res Care. 2020 Jul;8(1):e001126. doi: 10.1136/bmjdrc-2019-001126. PMID: 32699106 Free PMC article.
Structural characterization of life-extending Caenorhabditis Elegans Lipid Binding Protein 8.Tillman, M.C., Khadka, M., Duffy, D., Wang, M.C., Ortlund, E.A., Scientific Reports, 2019; 9, Article number: 9966
The effect of anticoagulants, temperature and time on the human plasma metabolome and lipidome from healthy donors as determined by liquid chromatography-mass spectrometry. Khadka, M., Todor, Andrei, A., Maner-Smith, K.M., Colucci, J.K., Tran, ViLinh, T., Gaul, D.A., Anderson, E., Natrajan, M., Rouphael, N., Mulligan, M.J., McDonald, C., Suthar, M., Li, S., Ortlund, E.A. Biomolecules 2019 May 23;9(5):200. doi: 10.3390/biom9050200. PMID: 31126114 Free PMC article.
Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. Regina Joice Cordy, Rapatbhorn Patrapuvich, Loukia N. Lili, Monica Cabrera-Mora, Jung-Ting Chien, Gregory K. Tharp, Manoj Khadka, Esmeralda V.S. Meyer, Stacey A. Lapp, Chester J. Joyner, AnaPatricia Garcia, Sophia Banton, ViLinh Tran, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, Nattawan Rachaphaew, Suman B. Pakala, Jeremy D. DeBarry, MaHPIC Consortium, Jessica C. Kissinger, Eric A. Ortlund, Steven E. Bosinger, John W. Barnwell, Dean P. Jones, Karan Uppal, Shuzhao Li, Jetsumon Sattabongkot, Alberto Moreno, and Mary R. Galinski. JCI Insight 2019 May 2;4(9):e125156. doi: 10.1172/jci.insight.125156
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. Abdul Malik Tyagi, Mingcan Yu, Trevor M. Darby, Chiara Vaccaro, Jau-Yi Li, Joshua A. Owens, Emory Hsu, Jonathan Adams, M. Neale Weitzmann, Rheinallt M. Jones, Roberto Pacifici. Immunity. doi.org:10.1016/j.immuni.2018.10.013
High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. Collins JM, Walker DI, Jones DP, Tukvadze N, Liu KH, Tran VT, Uppal K, Frediani JK, Easley KA, Shenvi N, Khadka M, Ortlund EA, Kempker RR, Blumberg HM, Ziegler TR. PLoS One. 2018 Oct 11;13(10):e0205398. doi: 10.1371/journal.pone.0205398. eCollection 2018.
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES. Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011