The investigational clinical microbiology core (ICMC) has been established to support banking and characterization of antibiotic resistant clinical isolates, environmental samples, and microbiome samples. The ICMC will help investigators by providing services for further research and characterization of important clinical pathogens and specimens. Often more laborious and sophisticated methods are needed issues of antibiotic resistance such as heteroresistance, or identify novel mechanism of resistance that are may be acquired through antibiotic exposure.
The ICMC has the capacity to perform the following:
- Detailed classification of antibiotic resistant clinical isolates
- Sophisticated antimicrobial susceptibility testing procedures not routinely available in clinical laboratories
- Studies of synergies between combinations of antibiotics
- Techniques to identify heteroresistance (looking for subpopulations with resistance)
- Molecular fingerprinting (PFGE), genomic characterization and analysis
- Collection and processing of clinical isolates and specimens
In addition, we have established the ICMC Biorepository. The ICMC biorepository contains a large collection of bacterial samples isolated by the Emory University Hospital (EUH) microbiology laboratory as part of standard patient care, environmental samples and microbiome samples. These normally discarded clinical samples and specimens are processed and stored in the ICMC biorepository and made available to investigators for the purpose of subsequent evaluation, mechanistic studies, clinical correlation or novel assay development. A corresponding database of all phenotypic laboratory characteristics of each isolate and important patient medical data is available.
The ICMC biorepository can help investigators access and store clinical isolates and specimens for future studies.