LC-MS analysis services

Our core facility provides comprehensive support to researchers through a wide range of mass spectrometry tools and techniques. We offer flexibility to meet your needs—trainees can receive hands-on training to perform their own LC-MS analyses, or our expert staff can run samples on your behalf.

Liquid Chromatography–Mass Spectrometry (LC-MS) enables precise molecular mass measurements and in-depth analysis of proteins, peptides, glycans, oligonucleotides, lipid and small molecule.

• Proteins, Peptides, and Antibodies
  LC-MS delivers insights into sample purity, folding states, dimer configuration, protein-protein interactions, post-translational modifications (PPTM).  We offer both top-down (analysis of intact proteins) and bottom-up (digestion followed by peptide analysis) workflows, depending on your experimental goals.
• Glycan Analysis
  We specialize in the analysis of glycosylation patterns and glycoform diversity in monoclonal antibodies. We utilize advanced workflows, including Agilent InstantPC tagging, for rapid and high-throughput N-glycan profiling.
• Oligonucleotide Validation
  LC-MS provides critical data for validating oligonucleotides, including sequence confirmation, purity assessment, and detection of structural modifications.

Our team is committed to helping you generate high-quality data and uncover meaningful biological insights. LC-MS analysis serves as a powerful tool for confirming product identity—whether you’ve ordered a synthetic peptide or produced a recombinant protein.

Based on our experience, over 10% of synthetic peptides from reputable suppliers are incorrectly synthesized, and approximately 25% of recombinant proteins include unexpected truncations or modifications. LC-MS validation ensures you’re working with the right material from the start.