Support for New Approach Methodologies


New Approach Methodologies (NAMs) rely on human-relevant cellular systems and advanced model platforms. Electron microscopy uniquely provides the ultrastructural and molecular validation needed to ensure these models faithfully reproduce biological reality.

At the IEMC, we help investigators:

  • Validate the structure and integrity of advanced in vitro systems
  • Quantify cellular responses to drugs, chemicals, and biologics
  • Reveal mechanisms at nanometer to near-atomic resolution
  • Generate mechanistic data that strengthens regulatory and translational impact

Electron microscopy provides the structural evidence layer that complements high-content screening, omics, and computational modeling.

Learn how IEMC services can support your research. Download the NAMs support slide here. 

How IEMC Strengthens NAM-Driven Research

Electron microscopy helps researchers:

  • Validate model fidelity
  • Demonstrate mechanism of action
  • Generate regulatory-grade visual evidence
  • Increase translational relevance
  • Strengthen grant proposals and publications

By integrating EM with NAM workflows, investigators can produce high-impact, human-relevant datasets that accelerate discovery and support regulatory acceptance.